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| Monday, July 29th, 2019 |
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| Traded 32-year-old closer Sean Doolittle to the Tampa Bay Rays, getting 28-year-old minor league starting pitcher Buck Farmer, 26-year-old minor league reliever Caleb Frare, 26-year-old minor league catcher Jamie Ritchie and 25-year-old minor league reliever Randy Rosario in return. |
| Sunday, July 28th, 2019 |
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| Traded 31-year-old first baseman Paul Goldschmidt to the New York Yankees, getting 32-year-old first baseman Jose Abreu, 23-year-old minor league second baseman Shedric Long and 25-year-old minor league first baseman Edwin Rios in return. |
| Thursday, July 18th, 2019 |
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| Optioned LF Mac Williamson to Triple A Nashville. |
| Placed LF Shin-Soo Choo on the active roster. |
| Activated LF Shin-Soo Choo from the injured list. |
| Saturday, June 22nd, 2019 |
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| Placed LF Shin-Soo Choo on the 10-day injured list, retroactive to 06/17/2019. |
| Purchased the contract of LF Mac Williamson from Triple A Nashville. |
| Monday, June 3rd, 2019 |
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| Optioned SP Steven Brault to Triple A Nashville. |
| Placed SP Chad Kuhl on the active roster. |
| Activated SP Chad Kuhl from the injured list. |
| Traded 28-year-old minor league catcher James McCann to the Tampa Bay Rays, getting 23-year-old minor league catcher Christopher Bec in return. |
| Friday, April 26th, 2019 |
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| Optioned CF Steven Duggar to Triple A Nashville. |
| Placed CF Guillermo Heredia on the active roster. |
| Activated CF Guillermo Heredia from the injured list. |
| Thursday, April 18th, 2019 |
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| Placed SP Chad Kuhl on the 10-day injured list, retroactive to 04/17/2019. |
| Purchased the contract of SP Jerad Eickhoff from Triple A Nashville. |
| Optioned CF Myles Straw to Triple A Nashville. |
| Purchased the contract of CF Steven Duggar from Triple A Nashville. |
| Sunday, April 14th, 2019 |
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| Optioned C James McCann to Triple A Nashville. |
| Placed C Kurt Suzuki on the active roster. |
| Saturday, April 13th, 2019 |
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| Traded 26-year-old minor league starting pitcher Zach Davies to the Atlanta Braves, getting 35-year-old catcher Kurt Suzuki and 23-year-old minor league first baseman Chad Spanberger in return. |
| Sunday, April 7th, 2019 |
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| 2B Max Schrock was designated for assignment and placed on waivers. |
| Optioned RP Tommy Eveld to Triple A Nashville. |
| Purchased the contract of C Martin Maldonado from Triple A Nashville. |
| Friday, March 29th, 2019 |
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| Assigned RF Chris Owings to Class A Stockton. |
| Placed CF Guillermo Heredia on the 10-day injured list, retroactive to 03/28/2019. |
| Purchased the contract of RF Myles Straw from Triple A Nashville. |
| Friday, March 22nd, 2019 |
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| Assigned 2B Edmundo Sosa to Class A Stockton. |
| RF Chris Owings was designated for assignment and placed on waivers. |
| Placed 2B Cory Spangenberg on the active roster. |
| Purchased the contract of RP Matt Barnes from Triple A Nashville. |
| Thursday, March 21st, 2019 |
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| 2B Edmundo Sosa was claimed off waivers from Houston. |
| Wednesday, March 20th, 2019 |
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| C Rene Rivera was claimed off waivers by Baltimore. |
| Assigned RP Dario Alvarez to Class A Stockton. |
| Purchased the contract of RP Tommy Eveld from Triple A Nashville. |
| Demoted C Martin Maldonado to Triple A Nashville. |
| 2B Cory Spangenberg was designated for assignment and placed on waivers. |
| Sunday, March 17th, 2019 |
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| Assigned C Bruce Maxwell from Spring Training camp to Triple A Nashville. |
| C Rene Rivera was designated for assignment and placed on waivers. |
| Optioned RF Chris Owings to Triple A Nashville. |
| Optioned CF Steven Duggar to Triple A Nashville. |
| Optioned LF Mac Williamson to Triple A Nashville. |
| Optioned 1B Luke Voit to Triple A Nashville. |
| Optioned RF Myles Straw to Triple A Nashville. |
| Optioned 3B Yandy Diaz to Triple A Nashville. |
| Assigned RP Dustin Beggs from Spring Training camp to Triple A Nashville. |
| Optioned RP Enyel De Los Santos to Triple A Nashville. |
| Optioned RP Blake Bivens to Triple A Nashville. |
| Optioned SP Zach Davies to Triple A Nashville. |
| Assigned RP Tommy Eveld from Spring Training camp to Triple A Nashville. |
| Optioned RP Sean Reid-Foley to Triple A Nashville. |
| Assigned RP Anyelo Gomez from Spring Training camp to Triple A Nashville. |
| Optioned RP Jerad Eickhoff to Triple A Nashville. |
| RP Dario Alvarez was designated for assignment and placed on waivers. |
| Friday, March 15th, 2019 |
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| Optioned CF Mike Tauchman to Triple A Nashville. |
| Assigned CF Jake Robson from Spring Training camp to Triple A Nashville. |
| Optioned RF Justin Williams to Triple A Nashville. |
| Monday, March 11th, 2019 |
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| Assigned LF Dilson Herrera from Spring Training camp to Triple A Nashville. |
| Assigned 3B Zach Houchins from Spring Training camp to Triple A Nashville. |
| Optioned 2B Max Schrock to Triple A Nashville. |
| Assigned 2B Jamie Westbrook from Spring Training camp to Triple A Nashville. |
| Designated 1B Albert Pujols for assignment. |
| Optioned 1B Nathaniel Lowe to Triple A Nashville. |
| Assigned RP Aaron Slegers from Spring Training camp to Triple A Nashville. |
| Assigned RP Tyler Wells from Spring Training camp to Triple A Nashville. |
| Assigned RP Chris Huffman from Spring Training camp to Triple A Nashville. |
| Optioned RP Matt Barnes to Triple A Nashville. |
| Assigned RP DeMarcus Evans from Spring Training camp to Double A Midland. |
| Thursday, February 14th, 2019 |
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| Invited non-roster RP Dario Alvarez to Spring Training camp. |
| Invited non-roster SP Dustin Beggs to Spring Training camp. |
| Invited non-roster RP DeMarcus Evans to Spring Training camp. |
| Invited non-roster RP Tommy Eveld to Spring Training camp. |
| Invited non-roster SP Anyelo Gomez to Spring Training camp. |
| Invited non-roster LF Dilson Herrera to Spring Training camp. |
| Invited non-roster 3B Zach Houchins to Spring Training camp. |
| Invited non-roster SP Chris Huffman to Spring Training camp. |
| Invited non-roster C Martin Maldonado to Spring Training camp. |
| Invited non-roster C Bruce Maxwell to Spring Training camp. |
| Invited non-roster CF Jake Robson to Spring Training camp. |
| Invited non-roster SP Aaron Slegers to Spring Training camp. |
| Invited non-roster SP Tyler Wells to Spring Training camp. |
| Invited non-roster 2B Jamie Westbrook to Spring Training camp. |
| Invited non-roster 2B Cory Spangenberg to Spring Training camp. |
| Wednesday, February 13th, 2019 |
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| Purchased the contract of CL Aaron Bummer from Triple A Nashville. |
| Purchased the contract of RF Myles Straw from Triple A Nashville. |
| Purchased the contract of SP Jerad Eickhoff from Triple A Nashville. |
| Purchased the contract of CF Mike Tauchman from Triple A Nashville. |
| Purchased the contract of RF Justin Williams from Triple A Nashville. |
| Purchased the contract of LF Mac Williamson from Triple A Nashville. |
| Purchased the contract of 2B Max Schrock from Triple A Nashville. |
| Purchased the contract of SP Enyel De Los Santos from Triple A Nashville. |
| Purchased the contract of 1B Nathaniel Lowe from Triple A Nashville. |
| Purchased the contract of SP Sean Reid-Foley from Triple A Nashville. |
| Wednesday, January 30th, 2019 |
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| Placed RP Blake Parker on the active roster. |
| Monday, January 28th, 2019 |
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| Assigned C Cam Gallagher to Triple A Nashville. |
| Traded 27-year-old minor league starting pitcher Daniel Poncedeleon and 22-year-old minor league right fielder Jose Azocar to the San Diego Padres, getting 19-year-old minor league starting pitcher Charlie Neuweiler and 33-year-old reliever Blake Parker in return. |
| Thursday, January 24th, 2019 |
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| Signed free agent RP Justin R. Miller to a 2-year contract worth a total of $9,000,000. |
| C Cam Gallagher was designated for assignment and placed on waivers. |
| Placed RP Justin R. Miller on the active roster. |
| Thursday, January 17th, 2019 |
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| Placed LF Mark Canha on the active roster. |
| Wednesday, January 16th, 2019 |
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| Signed free agent LF Mark Canha to a 2-year contract worth a total of $6,940,000. |
| Tuesday, January 15th, 2019 |
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| Optioned RP Matt Koch to Triple A Nashville. |
| Demoted RP Dario Alvarez to Triple A Nashville. |
| Placed 2B Freddy Galvis on the active roster. |
| Monday, January 14th, 2019 |
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| Signed free agent SS Freddy Galvis to a 5-year contract worth a total of $59,100,000. |
| Friday, January 11th, 2019 |
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| Placed RP Dario Alvarez on the active roster. |
| Placed RP Matt Koch on the active roster. |
| Friday, January 4th, 2019 |
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| Signed free agent 3B Eduardo Escobar to a 4-year contract worth a total of $69,600,000. |
| Placed 3B Eduardo Escobar on the active roster. |
| Placed CF Steven Duggar on the active roster. |
| RP Matt Koch was designated for assignment and placed on waivers. |
| RP Dario Alvarez was designated for assignment and placed on waivers. |
| Thursday, January 3rd, 2019 |
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| CF Steven Duggar was claimed off waivers from Detroit. |
| Wednesday, January 2nd, 2019 |
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| Placed C Rene Rivera on the active roster. |
