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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salazar, Alejandro | SS | Stockton Ports | 22 | 10/05/1996 | Cabimas | VEN | Right | Right | 6' 0" | 170 lbs | - |
| Salazar, Carlos | CL | Down East Wood Ducks | 23 | 11/23/1994 | Kerman | USA | Right | Right | 6' 0" | 200 lbs | - |
| Salinas, Raimfer | RF | Carolina Mudcats | 17 | 12/31/2000 | Ciudad Guayana | VEN | Right | Right | 6' 0" | 175 lbs | - |
| Salter, Blaise | 1B | Stockton Ports | 25 | 06/25/1993 | Bloomfield Hills | USA | Right | Right | 6' 5" | 245 lbs | - |
| Sanburn, Chandler | RP | Down East Wood Ducks | 23 | 07/08/1995 | Unknown | JPN | Left | Right | 5' 11" | 225 lbs | - |
| Sanchez, Ali | C | St. Lucie Mets | 21 | 01/20/1997 | Carora | VEN | Right | Right | 6' 0" | 195 lbs | - |
| Sanchez, David | CF | Jupiter Hammerheads | 19 | 01/06/1999 | Higüey | DOM | Right | Right | 6' 0" | 175 lbs | - |
| Sanchez, Frank | CF | Daytona Tortugas | 20 | 08/25/1998 | Sabana Grande de Palenque | DOM | Right | Right | 6' 3" | 170 lbs | - |
| Sanchez, Jesus Armando | RF | Lynchburg Hillcats | 21 | 10/07/1997 | Higüey | DOM | Left | Right | 6' 3" | 210 lbs | - |
| Sanchez, Ricardo | RP | Palm Beach Cardinals | 21 | 04/11/1997 | Puerto Cabello | VEN | Left | Left | 5' 10" | 215 lbs | - |
| Sanchez, Santis | C | Lynchburg Hillcats | 20 | 08/21/1998 | Las Piedras | PUR | Right | Right | 6' 0" | 200 lbs | - |
| Sandoval, Ariel | RF | Fort Myers Miracle | 23 | 11/06/1995 | Sabana Grande de Boya | DOM | Right | Right | 6' 2" | 180 lbs | - |
| Sanger, Brendon | 2B | Rancho Cucamonga Quakes | 25 | 09/11/1993 | York | USA | Left | Right | 6' 0" | 195 lbs | - |
| Santana, Cristian | 3B | Carolina Mudcats | 21 | 02/24/1997 | San Cristóbal | DOM | Right | Right | 6' 2" | 175 lbs | - |
| Santana, Debby | 1B | Florida Fire Frogs | 18 | 08/24/2000 | Sabana Grande de Palenque | DOM | Right | Right | 6' 2" | 185 lbs | - |
| Santana, Juan | RF | Winston-Salem Dash | 17 | 07/17/2001 | La Romana | DOM | Left | Left | 6' 2" | 180 lbs | - |
| Santana, Luis | 2B | Potomac Nationals | 19 | 07/20/1999 | Baní | DOM | Right | Right | 5' 8" | 175 lbs | - |
| Santana, Martin | CL | San Jose Giants | 17 | 01/30/2001 | Higüey | DOM | Right | Right | 6' 3" | 165 lbs | - |
| Santana Jr., Andres | CF | Myrtle Beach Pelicans | 20 | 11/05/1998 | Miami | USA | Right | Right | 6' 0" | 180 lbs | - |
| Santos, Gregory | RP | Carolina Mudcats | 19 | 08/28/1999 | San Cristóbal | DOM | Right | Right | 6' 2" | 190 lbs | - |
| Schales, Brian | 3B | Lynchburg Hillcats | 22 | 02/13/1996 | Huntington Beach | USA | Right | Right | 6' 0" | 170 lbs | - |
| Schaller, Reid | RP | Clearwater Threshers | 21 | 04/02/1997 | Lebanon | USA | Right | Right | 6' 3" | 210 lbs | - |
| Scheftz, Jordan | CL | Myrtle Beach Pelicans | 23 | 08/31/1995 | Irvine | USA | Right | Right | 6' 3" | 190 lbs | - |
| Schneider, Davis | RF | Frederick Keys | 19 | 01/26/1999 | Berlin | USA | Right | Right | 5' 10" | 190 lbs | - |
| Schnell, Nick | LF | Jupiter Hammerheads | 18 | 03/27/2000 | Indianapolis | USA | Left | Right | 6' 3" | 180 lbs | - |
| Scioneaux, Tate | RP | Modesto Nuts | 25 | 12/14/1992 | Reserve | USA | Right | Right | 6' 0" | 200 lbs | - |
| Scott, Adam | SP | Down East Wood Ducks | 23 | 10/10/1995 | Canandaigua | USA | Left | Left | 6' 3" | 220 lbs | - |
| Sedlock, Cody | SP | Rancho Cucamonga Quakes | 23 | 06/19/1995 | Unknown | USA | Right | Right | 6' 3" | 190 lbs | - |
| Seigler, Anthony | C | Modesto Nuts | 19 | 06/20/1999 | Cartersville | USA | Switch | Right | 6' 0" | 200 lbs | - |
| Seijas, Karlo | RP | Charlotte Stone Crabs | 18 | 09/06/2000 | La Victoria | VEN | Right | Right | 6' 0" | 185 lbs | - |
| Serrano, Elvin | SP | Lancaster JetHawks | 19 | 02/15/1999 | San Francisco de Macorís | DOM | Right | Right | 6' 0" | 180 lbs | - |
| Severino, Yunior | 2B | Palm Beach Cardinals | 19 | 10/03/1999 | Santo Domingo | DOM | Switch | Right | 6' 0" | 190 lbs | - |
| Sheets, Gavin | 1B | Stockton Ports | 22 | 04/23/1996 | Lutherville-Timonium | USA | Left | Left | 6' 3" | 230 lbs | - |
| Shetter, Ryan | RP | Salem Red Sox | 21 | 03/05/1997 | Friendswood | USA | Right | Right | 6' 3" | 205 lbs | - |
| Shipley, Braden | RP | Frederick Keys | 26 | 02/22/1992 | Medford | USA | Right | Right | 6' 0" | 190 lbs | - |
| Siani, Mike | CF | Down East Wood Ducks | 19 | 07/16/1999 | Glenside | USA | Left | Left | 6' 0" | 180 lbs | - |
| Sierra, Jonathan | RF | Modesto Nuts | 20 | 10/17/1998 | Santo Domingo | DOM | Left | Left | 6' 3" | 190 lbs | - |
| Silverio, Gresuan | C | Potomac Nationals | 19 | 01/05/1999 | Puerto Plata | DOM | Switch | Right | 6' 0" | 175 lbs | - |
| Simmons, Logan | SS | Inland Empire 66ers | 18 | 04/11/2000 | Macon | USA | Right | Right | 6' 2" | 180 lbs | - |
| Simon, Jake | SP | St. Lucie Mets | 21 | 01/21/1997 | Galveston | USA | Left | Left | 6' 2" | 190 lbs | - |
| Skender, Ethan | 3B | Frederick Keys | 21 | 12/22/1996 | Metamora | USA | Right | Right | 5' 10" | 175 lbs | - |
| Smith, Canaan | RF | Lakeland Flying Tigers | 19 | 04/30/1999 | Rockwall | USA | Left | Right | 6' 0" | 215 lbs | - |
| Smith, Hugh | SP | St. Lucie Mets | 21 | 03/25/1997 | Sammamish | USA | Right | Right | 6' 9" | 215 lbs | - |
| Smith, Isaiah | CF | Stockton Ports | 19 | 06/19/1999 | Battle Ground | USA | Right | Right | 6' 3" | 190 lbs | - |
| Snyder, Nick | RP | Salem Red Sox | 23 | 10/10/1995 | Palm City | USA | Right | Right | 6' 3" | 190 lbs | - |
| Sodders, Austin | SP | Rancho Cucamonga Quakes | 23 | 04/29/1995 | Riverside | USA | Left | Left | 6' 3" | 205 lbs | - |
| Solarte, Angel | CF | Daytona Tortugas | 17 | 03/29/2001 | Unknown | VEN | Right | Right | 5' 10" | 155 lbs | - |
| Solarte, Jhon | CF | Buies Creek Astros | 17 | 12/09/2000 | Unknown | VEN | Switch | Right | 6' 0" | 165 lbs | - |
| Soler, Carlos | RF | Buies Creek Astros | 19 | 10/29/1999 | San Pedro de Macorís | DOM | Left | Right | 6' 2" | 165 lbs | - |
| Solis, Jairo | RP | Potomac Nationals | 18 | 12/22/1999 | Puerto Cabello | VEN | Right | Right | 6' 2" | 160 lbs | - |
| Solorzano, Yosmer | RP | Florida Fire Frogs | 21 | 02/11/1997 | Unknown | VEN | Right | Right | 6' 2" | 180 lbs | - |
| Soria, Zack | C | Charlotte Stone Crabs | 25 | 10/29/1993 | Homer Glen | USA | Right | Right | 5' 10" | 190 lbs | - |
| Soriano, Jose | RP | Carolina Mudcats | 20 | 10/20/1998 | Santo Domingo | DOM | Right | Right | 6' 3" | 170 lbs | - |
| Sosa, Lenyn | 3B | Lakeland Flying Tigers | 18 | 01/25/2000 | Puerto Cabello | VEN | Right | Right | 6' 0" | 180 lbs | - |
| Sosa, Onliber | RP | Clearwater Threshers | 21 | 11/04/1997 | Tenares | DOM | Right | Right | 6' 0" | 195 lbs | - |
| Soto, Livan | 2B | Carolina Mudcats | 18 | 06/22/2000 | Valencia | VEN | Left | Right | 6' 0" | 160 lbs | - |
| Spanberger, Chad | 1B | Florida Fire Frogs | 23 | 11/01/1995 | Granite City | USA | Left | Right | 6' 3" | 235 lbs | - |
| Sparkman, Glenn | RP | Fort Myers Miracle | 26 | 05/11/1992 | Ganado | USA | Switch | Right | 6' 2" | 210 lbs | - |
| Spears, Zach | RP | Salem Red Sox | 21 | 06/03/1997 | Greenfield | USA | Left | Left | 6' 7" | 235 lbs | - |
| Speas, Alex | SP | Lake Elsinore Storm | 20 | 03/04/1998 | Powder Springs | USA | Right | Right | 6' 3" | 180 lbs | - |
| Spillane, Brenden | 3B | Inland Empire 66ers | 22 | 09/21/1996 | Unknown | USA | Right | Right | 6' 3" | 210 lbs | - |
| Spitzbarth, Shea | RP | Fort Myers Miracle | 24 | 10/04/1994 | New York | USA | Right | Right | 6' 0" | 195 lbs | $545,000 |
| Spiwak, Owen | C | Palm Beach Cardinals | 23 | 05/23/1995 | Toronto | CAN | Left | Right | 6' 2" | 185 lbs | - |
| Stafford, Deon | C | Wilmington Blue Rocks | 22 | 03/17/1996 | Harrisburg | USA | Right | Right | 5' 10" | 210 lbs | - |
| Stashak, Cody | RP | Fort Myers Miracle | 24 | 06/04/1994 | Somers Point | USA | Right | Right | 6' 2" | 170 lbs | - |
| Stauffer, Adam | RP | Winston-Salem Dash | 19 | 01/13/1999 | Coatesville | USA | Right | Right | 6' 7" | 240 lbs | - |
| Stewart, Carter | SP | St. Lucie Mets | 19 | 11/02/1999 | Melbourne | USA | Right | Right | 6' 5" | 200 lbs | - |
| Stobbe, Cole | 3B | Carolina Mudcats | 21 | 08/30/1997 | Omaha | USA | Right | Right | 6' 2" | 195 lbs | - |
| Strotman, Drew | SP | Visalia Rawhide | 22 | 09/03/1996 | Sunnyvale | USA | Right | Right | 6' 3" | 195 lbs | - |
| Susi, Zac | C | Free Agent | 22 | 10/30/1996 | Southington | USA | Left | Right | 6' 0" | 200 lbs | - |
| Swaggerty, Travis | CF | Wilmington Blue Rocks | 21 | 07/19/1997 | Denham Springs | USA | Left | Left | 5' 10" | 180 lbs | - |
| Szynski, Skylar | RP | Potomac Nationals | 21 | 07/14/1997 | Granger | USA | Left | Right | 6' 2" | 195 lbs | - |
